PIM Inhibition Decreases Hepatoblastoma Tumor-Initiating Cell Phenotype
نویسندگان
چکیده
منابع مشابه
IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts.
Igf2 mRNA binding protein 1 (IMP1, CRD-BP, ZBP-1) is a messenger RNA binding protein that we have shown previously to regulate colorectal cancer (CRC) cell growth in vitro. Furthermore, increased IMP1 expression correlates with enhanced metastasis and poor prognosis in CRC patients. In the current study, we sought to elucidate IMP1-mediated functions in CRC pathogenesis in vivo. Using CRC cell ...
متن کاملPKCi Maintains a Tumor-initiating Cell Phenotype That Is Required for Ovarian Tumorigenesis
Protein kinase Ci (PKCi) has oncogenic potential and is an attractive therapeutic target for treatment of lung cancer, particularly those tumors that express elevated PKCi. However, whether PKCi is a viable target in ovarian cancer is unknown, and virtually nothing is known about the mechanism by which PKCi drives ovarian tumorigenesis. Here, it is demonstrated that PKCi maintains a tumor-initi...
متن کاملPKCι maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis.
UNLABELLED Protein kinase Cι (PKCι) has oncogenic potential and is an attractive therapeutic target for treatment of lung cancer, particularly those tumors that express elevated PKCι. However, whether PKCι is a viable target in ovarian cancer is unknown, and virtually nothing is known about the mechanism by which PKCι drives ovarian tumorigenesis. Here, it is demonstrated that PKCι maintains a ...
متن کاملTargeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency.
PURPOSE The Notch pathway plays an important role in both stem cell biology and cancer. Dysregulation of Notch signaling has been reported in several human tumor types. In this report, we describe the development of an antibody, OMP-59R5 (tarextumab), which blocks both Notch2 and Notch3 signaling. EXPERIMENTAL DESIGN We utilized patient-derived xenograft tumors to evaluate antitumor effect of...
متن کاملInitiating inhibition
A recent publication by Schellmann et al. (2002) in The EMBO Journal has provided important insights into the control of cell fate and pattern formation in plants. To study the underlying molecular mechanisms, the authors made use of the development of root hairs and trichomes in Arabidopsis thaliana. A. thaliana trichomes are large, unicellular structures that project out from the shoot epider...
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ژورنال
عنوان ژورنال: Journal of the American College of Surgeons
سال: 2017
ISSN: 1072-7515
DOI: 10.1016/j.jamcollsurg.2017.07.346